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These drugs work by mimicking the action of certain hormonesprimarily GLP-1 (glucagon-like peptide-1)that play a key role in regulating blood sugar and appetite

[DOI] [PubMed] [Google Scholar] 11.Wong TY, Sun J, Kawasaki R, et al

Biochem Biophys Res Commun 298:779784 Maida A, Lamont BJ, Cao X, Drucker DJ (2011) Metformin regulates the incretin receptor axis via a peroxisome proliferator-activated receptor alpha-dependent pathway in mice

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doi: 10.3389/fpubh.2018.00141 54 KlumpKLKeelPKCulbertKM

A summary of preclinical effects of GLP-1 on hepatic tissue is presented in Table 2