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Patients who used Zepbound for 36 weeks lost an average of 21%, but then, when switched to a placebo, after 1 year, they had regained 14% of their weight back

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Tirzepatide, however, activates both the GLP-1 receptor and a second hormone pathway called glucose-dependent insulinotropic polypeptide (GIP), producing greater improvements in insulin sensitivity, weight loss and metabolic inflammation