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Head-to-head post-registration trial or a real-world data study would be helpful

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Both glucagon-like peptide-1 receptor agonists (GLP-1RA) and sodium-glucose cotransporter-2 (SGLT-2) inhibitors can reduce CV risk in patients with T2D, and both are recommended by the American Diabetes Association to reduce the risk of major cardiovascular events (MACE)

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In this article, we review the latest research to highlight when these medications might offer the greatest benefit for patients with substance use disorders.