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Factors That Influence Your Semaglutide Dose Your ideal semaglutide dose depends on multiple factors: your starting weight, metabolism, kidney and liver function, other medications you take, and how your body tolerates GLP-1 activation

Beverly Tchang, an endocrinologist and obesity medicine physician at Weill Cornell Medicine in New York, previously told TODAY.com

a Weight loss was a secondary endpoint in clinical trials

Retatrutide is an investigational triple agonist targeting GLP-1, GIP, and glucagon receptors, under active clinical evaluation

They can also advise on meal timing and portion control for better results

12mg weekly: maximum therapeutic effect (weeks 13+) The 12mg maintenance dose represents the highest studied dose and produces the strongest appetite effects