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doi: 10.1056/NEJMoa2306963, PMID: [DOI] [PubMed] [Google Scholar] 157

Clinical and observational studies provide preliminary support for these findings, particularly among individuals with comorbid obesity or insulin resistance

The clinical data suggesting a possible association come from post-marketing surveillance data that have substantial risk for bias and do not control for important confounding variables

Off-label use for low-BMI cosmetic weight loss is not supported by the evidence, exposes the patient to real risks (including rapid muscle loss and rebound after discontinuation), and typically isn't covered by insurance