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In this case, the patient's predicament may have been caused by a higher-than-recommended starting dose of semaglutide

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Interestingly, some of them are able to cross the bloodbrain barrier and act on the brain to stimulate satiety [2], which leads to food intake reduction and, consequently, body weight loss, which occurs at the expense of fat mass

Orlistat is generally the least favored option due to its side effect profile, and its benefit is reduced if an individual is already following a low-fat diet, although gastrointestinal side effects may persist

Additionally, GLP-1 activates related intracellular signaling pathways, promoting -cell regeneration, inhibiting -cell apoptosis, and improving -cell function, thereby lowering blood glucose levels, with its effects being glucose concentration-dependent (58, 59)

Exendin-4 and eldecalcitol synergistically promote osteogenic differentiation of bone marrow mesenchymal stem cells through M2 macrophages polarization via PI3K/AKT pathway