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doi: 10.1152/ajpendo.00463.2010

The evidence is strong: an individual patient data meta-analysis showed a 39% reduction in decompensation risk in compensated cirrhosis, and the PREDESCI trial showed roughly a 40% reduction in first decompensation over 2 years

It is recommended that clinicians and pharmacists strongly prioritise the use of these medications for their appropriate T2D PBS/RPBS indication in the immediate future (Table 1), until abundant supply can be guaranteed nationwide

Animal studies

Patients experiencing nausea should be advised to: Eat smaller, more frequent meals rather than large portions Avoid high-fat, greasy, or heavily spiced foods that may exacerbate nausea Stay well-hydrated with small, frequent sips of water Consider bland foods such as crackers, toast, or rice during symptomatic periods Avoid lying down immediately after eating For constipation , increasing dietary fibre intake through fruits, vegetables, and whole grains, alongside adequate fluid consumption (1.5-2 litres daily), often provides relief

People who are overweight have a 32% higher risk of developing coronary heart disease, while those with obesity have an 81% higher risk