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Diabetologia 2015;58:263746

Patients with T2DM and obesity exhibit an elevated risk of adverse cardiovascular events

Formulation variations - Compounded versions may differ in inactive ingredients (preservatives, stabilizers, pH adjusters) from brand-name products, which can affect tolerability for some individuals

Maternal prepregnancy overweight and obesity and the risk of preeclampsia: a meta-analysis of cohort studies

PMID: 33760905 Aroda VR et al (2016): Long-term Metformin Use and Vitamin B12 Deficiency in the Diabetes Prevention Program Outcomes Study

Nausea is by far the most common side effect, appearing in roughly 5070% of users, especially during the early stages of treatment