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Lastly, health-system integration is complicated by uncertainties in reimbursement and regulatory classification (e.g., whether device, drug-device combination, or medicinal product), and postpones large, late-phase clinical trials

However, lasting results typically happen gradually over several months of consistent use and healthy lifestyle changes

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Subsequent studies showed male and female mice globally deficient for GLP1 receptors were paradoxically protected against dietinduced weightgain (Table 2) (Ayala et al., 2010