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Overall, we identified 280 pre-clinical and mechanistic studies (Fig

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Each approach addressed one or two of the three barriers to oral peptide delivery but none comprehensively solved all three simultaneously

#MASH #Hepatology #MetabolicHealth #GLP1 To view or add a comment, sign in Narrative review proposes pancreatic exocrine fibrosis and profibrotic signalling as key drivers of type 3c diabetes, with a potential role in type 2 and type 1 diabetes, and summarises unanswered questions & suggests potential novel therapeutic targets To view or add a comment, sign in We are very grateful to Diabetologia for inviting us to review the growing evidence supporting a profibrotic signalling cycle involving stellate cells, macrophages and islet endocrine cells themselves in the pathogenesis of pancreatogenic diabetes including diabetes associated with pancreatic cancer