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In vitro, mouse pancreatic -cells (NIT-1 cells) were exposed to palmitic acid (PA), PA+exendin-4 (Ex-4), PA+GW, PA+GSK0660 (GSK, a PPAR antagonist), or PA+Ex-4+GSK

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As GLP-1 receptor agonists, these peptide drugs mimic the incretin hormone GLP-1, enhancing glucose-dependent insulin secretion, suppressing glucagon release, delaying gastric emptying, and reducing appetite [9]