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This milestone reflects a closely integrated development-to-submission model, with Orbicular leading product development and OneSource supporting the program as the CDMO partner for manufacturing and supply readiness

Cessation is consistently linked to rebound weight gain, and retrospective data suggest greater gestational weight gain and higher risks (e.g., preterm delivery, GDM, hypertensive disorders) after stoppingthough causality remains uncertain

All participants underwent continuous glucose monitoring (CGM) for three consecutive days, then TIR and glycemic variability (GV) parameters were evaluated

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