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A Study of Retatrutide (LY3437943) in Participants With Obesity and Cardiovascular Disease (TRIUMPH-3)

It is probably broken down before it can reach CNS GIP receptors

A 2022 systematic review in Obesity Reviews found that GLP-1 associated weight loss showed comparable or slightly better muscle preservation than diet-only approaches
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Leger, M

GLP1 receptor agonists and the path to sustainable obesity care
