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These are usually most prominent in the first 48 to 72 hours after the first injection of a higher dose

One of the most frequent concerns patients bring is the rebound effect

The practical recommendation: use 1 mL of water for the 10 mg/mL concentration unless you find very small volumes difficult to measure accurately

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At the same time, other clinical and observational studies have reported neutral or potentially protective effects of GLP-1 drugs on brain health

National Academies Press (US)