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This suggests that the agency is using 704(a)(4) requests as a strategic tool for international facilities, likely for the purpose of utilizing resources efficiently

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The slight difference in results is not clinically significant, and individual results vary based on adherence to diet and exercise recommendations

Targeting both receptors simultaneously, as with tirzepatide, leverages these complementary effects, enhancing insulin secretion [3], reducing appetite, improving insulin sensitivity, and supporting weight loss more effectively than single receptor agonists

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ATTAIN-1 (NCT05869903) The key trial for the obesity indication, ATTAIN-1 randomized 3,127 adults with obesity or overweight (without diabetes) to orforglipron 6 mg, 12 mg, or 36 mg versus placebo for 72 weeks