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Importantly, in humans GLP-1RAs, such as semaglutide in the setting of type 2 diabetes (T2D) treatment, reduce the risk of cardiovascular death, nonfatal myocardial infarction, and nonfatal stroke [95]

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Lifestyle modifications remain the cornerstone of safe weight management: Dietary interventions : A modest calorie deficit (typically 500600 kcal/day) achieved through balanced nutrition rather than restrictive dieting

She said in a statement that semaglutide provides a new way for physicians to address the resulting effects of obesity and diabetes." Semaglutide has ushered in a new era of medications for weight loss and the results of the SELECT study are showing that its benefits extend beyond that of treating obesity, she said

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