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Personalised dose escalation, nutritional guidance, hydration support and regular follow-up help minimise side effects while supporting safer, more sustainable outcomes

Side effects Nausea (38-43% depending on dose most common side effect, typically peaks during titration and improves after 8-12 weeks of gradual dose escalation) Diarrhea (33-35% dose-dependent, usually mild to moderate severity, manageable with dietary adjustments) Vomiting (20-21% more common at higher doses and during rapid titration, often resolves with slower dose escalation) Constipation (22-25% can occur alternately with diarrhea during dose adjustment periods) Decreased appetite (18-19% related to GLP-1 mechanism of action, distinct from nausea-related food avoidance) Dysesthesia (8.8% at 9 mg, 20.9% at 12 mg vs 0.7% placebo NEW safety signal identified in Phase 3 TRIUMPH-4, not observed in Phase 2

Just ensure the ambient temperature stays under 86F

These drugs were made to last much longer, so they keep working in your body to help: Lower blood sugar Make you feel full Help you lose weight

Glucagon Receptor: Increases energy expenditure and influences hepatic fat metabolism

[DOI] [PMC free article] [PubMed] [Google Scholar] 33.Roman CW, Derkach VA, Palmiter RD