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Taken together, these results suggest that the vagus nerve is involved in a key GLP-1 signal transduction pathway that modulates locomotor activity in gut microbiota-deficient mice

For example, one study showed that although people treated for 68 weeks with semaglutide (2.4 mg/week) lost an average of 18% of their initial body weight, the majority of this weight was regained within a year following discontinuation of treatment (Figure 7)

AstraZeneca PLC AstraZeneca is strengthening its portfolio with GLP-1 targeted drugs and actively engaging in clinical trials for obesity-related metabolic conditions

In addition, the researchers said those taking the GLP-1 drugs also experienced decreased risks of suicidal ideation, self-harm, bulimia and psychotic disorders such as schizophrenia