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2 Here, we present a comparative live cell binding analysis of three distinct ligand classes targeting the GLP-1R overexpressed in HEK293 cells: the small molecule orforglipron (an FDA-approved GLP-1R agonist), the peptide semaglutide (a widely studied GLP-1 analog for weight loss and inflammation), and an anti-GLP-1R monoclonal antibody directed against the extracellular domain (ECD)

Mechanisms of peptide and nonpeptide ligand binding to Class B G-protein-coupled receptors

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Heavy alcohol consumption while on Tirzepatide is not recommended as it can increase the risk of pancreatitis

Goodrick, G

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