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Description
AgRP is an antagonist of alpha-MSH at MC3Rs and MC4Rs prevents their activation, whereas GABA inhibits the POMC/CART neurons
Note: These timelines are based on glucagon pharmacology and the known titration schedule, not formally measured temperature endpoints from TRIUMPH trials

Treatment usually starts with 3 mg once daily for 30 days, then increases to 7 mg once daily
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Why the Big Difference

Steady dose escalation to higher doses than for glycaemic control are indicated if: BMI is 30 kg/m 2 , or BMI 27 to 30 kg/m 2 , and for the range 2730 kg/m 2 if there is one weight-related comorbidity (hypertension, dyslipidaemia, cardiovascular disease, obstructive sleep apnoea, prediabetes or T2D

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