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Keywords: GLP-1 receptor agonists, Neuroprotection, Synaptic plasticity, Central nervous system, Neurodegenerative diseases Graphical abstract Introduction GLP-1 receptor agonists (GLP-1RAs) are well-established treatments for type 2 diabetes mellitus (T2DM) and obesity, providing effective glycemic control, weight loss, and cardiovascular benefits [[1], [2], [3]]

This correlation does not tell us whether the symptom improvement was driven by weight loss, direct anti-inflammatory effects, or both, but it confirms that the metabolic improvements tracked alongside the symptom improvements

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T2D: type 2 diabetes

Slow dose titration helps minimize discomfort