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Clinical trials have also demonstrated that Ozempic lowers the risk of significant cardiovascular events such heart attacks and strokes, which is a significant benefit not directly offered by insulin

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Endocrinology 149, 40594068

The [pre-] history of the incretin concept

Inhibition of glucagon secretion or antagonism of glucagon receptors has become a potentially effective treatment strategy for T2DM patients (Lund et al., 2014)

2025: FDA expanded indication oral semaglutide now approved to reduce major cardiovascular events (MACE) in adults with T2DM at high CV risk