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LC-MS provides the structural resolution necessary to perform these comparisons accurately

Sandsdal et al

127129 They designed GLP-1 peptidomimetics ( 21 ) by replacing a helical peptide segment in GLP-1 with a corresponding tris-benzamide-based helix mimetic (e.g., SH3), which showed promising receptor binding and potency (EC 50 = 130 nM

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What we observe is indirect modulation: weight loss and improved metabolic health alter the hormonal milieu, which, in turn, can shift menstrual regularity, ovulatory function, and androgen balance in predictable ways