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Poor sleep increases ghrelin (hunger hormone) and decreases leptin (satiety hormone), making weight loss more difficult

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Bipolar depression treatment has limited evidence, although lots of drugs have been proposed as treatment options with similar efficacy but varying tolerability, such as lamotrigine, fluoxetine or antipsychotics as quetiapine or olanzapine, among others [236,237,238]

Key facts: Medicaid launch : as early as May 2026 Participation : voluntary for states states must opt in Pricing : CMS negotiates directly with Eli Lilly (Zepbound/Mounjaro) and Novo Nordisk (Wegovy/Ozempic)