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Very positive experience

Secretion of Exe4 peptide via gene knock-in in Hepa1-6 cells To achieve sustained Exe4 secretion, we targeted the Albumin ( Alb ) locus due to its hepatocyte-specific high expression levels, ensuring robust expression of the integrated scExe4 gene 9,33,34

These preclinical findings support clinical trial results showing that tirzepatide, a dual GIPR/GLP-1R agonist, exhibits greater anti-obesity effects than GLP-1 receptor agonists alone

The study also indicates a progressive trend, with Wegovy, recognized as the most potent GLP-1 RA, administered at the highest dose and renowned for its remarkable reduction in body weight

Im quite happy to put up with it to keep this weight going down. (P5, female, obesity)

[DOI] [PubMed] [Google Scholar] [29].Panunzi C, Cardinali F, Khalil A, et al