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however, randomized controlled trials and a large international cohort study have shown no increases in thyroid cancer risk in humans.[7779] Isolated study findings have also raised concerns about ocular adverse events, including retinopathy and non-arthritic anterior ischemic optic neuropathy (NAION).[11, 80] However, to date, meta-analyses have failed to find associations between GLP-1RAs and NAION, and only albiglutide, a GLP-1RA discontinued in 2017, has been associated with an increased risk of retinopathy.[80, 81] In adults 66 years and older with diabetes, a cohort study found a two-fold increase in risk for neovascular age-related macular degeneration in those using GLP-1RAs for one year or more.[82] Accessibility Despite the expanding indications and potential therapeutic benefits of GLP-1RAs, disparities in cost-related access may hinder their utilization in populations that stand to benefit the most.[83] In the U.S., individuals identifying as Hispanic and non-Hispanic Blackgroups with higher obesity prevalencedemonstrate significantly lower initiation rates of GLP-1RAs compared to individuals identifying as White.[83, 84] Additionally, individuals enrolled in Medicaid, Medicare, or lacking insurance are less likely to initiate GLP-1RA therapy relative to those with private insurance coverage

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These medications may slow the progression of osteoarthritis, not just through weight loss but by directly interacting with cells within the joint to slow the progression of the development of osteoarthritis, which is pretty profound, Heckmann said

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Fermented foods like kefir, sauerkraut, kimchi, and live yoghurt support gut microbiome diversity, indirectly enhancing GLP-1 production

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These issues now form the foundation of coordinated legal actions involving Trulicity and other GLP-1 medications: Trulicity is included because it belongs to the same GLP-1 drug class as other medications under scrutiny, and lawsuits claim that class-wide effects on gut motility may be relevant to the injuries alleged

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