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For patients requiring additional glycaemic control, the dose may be increased to the maximum licensed dose of 2 mg once weekly after at least four weeks at the 1 mg dose, as per the UK SmPC

Regarding the cellular localization of GLP-1R in the CNS, there are controversial findings

The three body areas most commonly used for subcutaneous injections of this type are: The abdomen the area around the stomach, at least 5 cm away from the navel The front of the thigh (anterolateral, mid-thigh) the outer-front portion of either thigh The outer upper arm the fatty area of the upper arm (usually easier when administered by a carer or healthcare professional) These areas are preferred because they contain sufficient subcutaneous adipose tissue for reliable drug absorption

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By understanding the nuances of how semaglutide influences hormone levels and interacts with HRT, healthcare providers can better navigate its use in treating obesity, diabetes, and hormonal imbalances

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