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Cardiovascular Effects Dose-dependent increases in heart rate were observed with retatrutide: Heart rate increases peaked at approximately 24 weeks Gradually declined thereafter while remaining elevated above baseline This pattern is similar to that observed with other GLP-1 receptor agonists[4] The clinical significance of these heart rate changes requires further evaluation in larger and longer-term studies

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Use this tirzepatide dosage calculator to estimate syringe units per dose and how long a vial will last based on vial size, water volume, and amount per dose.

Seek advice if it is severe, persistent, affects eating or drinking, or appears with symptoms such as vomiting, dehydration, dizziness, increased thirst or blood sugar concerns