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Although early rodent studies raised concerns about thyroid cancer risk, the expanding body of human evidence on GLP-1 therapy and thyroid cancer risk offers increasing reassurance

Sin embargo, en los anlisis de subgrupos de los estudios de seguridad cardiovascular la HbA1c basal, el peso, la enfermedad cardiovascular previa o la funcin renal no predecan los efectos beneficiosos sobre los MACE de estos frmacos87, por lo que se ha sugerido que otros mecanismos, como los efectos antiinflamatorios, antifibrticos, antiaterognicos, vasodilatadores o de mejora de la funcin endotelial, previamente mencionados, influyan en el beneficio cardiovascular de estos frmacos29,78 (fig

Patients interested in similar treatments should discuss currently approved alternatives with their healthcare providers.

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