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A subset of these patients developed neutralizing antibodies (NAbs) capable of inhibiting Tirzepatide's activity at the GIP and GLP-1 receptors in vitro, but the incidence was low (1.9% and 2.1%, respectively)

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Patients in the semaglutide or tirzepatide group had an increased incidence of other optic disc disorders, but this difference was not statistically significant (Figure 2)
