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A history of depression, suicidal thoughts, or mental health issues

Assess potential risks of GLP-1As in patients with or at-risk of developing an eating disorder

(NYSE:LLY) announced data from the Phase III TRIUMPH-4 study of retatrutide in obese patients with osteoarthritis that showed placebo-adjusted weight loss of up to 26.6%
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It has therefore been postulated that the administration of molecules capable of mimicking the action of GLP-1 and/or GIP could reproduce this incretin effect and thus stimulate insulin production and improve glycemic control in type 2 diabetics

Curr Neuropharmacol (2020) 18(11):110625
