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Brian Wojeck, an obesity medicine specialist at the Yale School of Medicine, likened it to what happens after bariatric surgery, in which patients often experience temporary shedding due to stress and rapid metabolic change

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In the phase 2 trial, participants started at 4 mg without escalation experienced significantly more adverse events than those who began at 2 mg

Researchers emphasised the significance of this discovery, as physicians tend to refrain from prescribing GLP-1RAs to individuals who have previously experienced pancreatitis

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[DOI] [PMC free article] [PubMed] [Google Scholar] 63.Friedrichsen, M., Endahl, L., Kreiner, F.F., Goldwater, R., Kankam, M., Toubro, S., and Nygrd, S.B