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4 Concluding remarks, place in therapy, and future perspective Tirzepatide is a novel agent that is approved for the treatment of type 2 diabetes and will likely be approved for weight loss

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When appetite decreases, nutrition has to work harder

doi: 10.1016/j.diabet.2008.09.007

Gastrointestinal and Pancreatic Safety Concerns Gastrointestinal adverse effects are the most commonly reported side effects of GLP-1RAs

The primary mechanisms include: Enhanced insulin secretion in response to elevated blood glucose levels, helping to lower blood sugar in people with type 2 diabetes Suppression of glucagon release from the pancreas, reducing glucose production by the liver Delayed gastric emptying , which slows the movement of food from the stomach into the small intestine Increased satiety through actions on appetite centres in the brain, leading to reduced food intake The slowing of gastric emptying is particularly significant when considering electrolyte balance