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However, 9.6% is still substantial weight loss, and diabetic patients also experience significant blood sugar improvements (average HbA1c reduction of 1.6 percentage points)

These effects appear to be mediated through modulation of dopamine signaling in the mesolimbic reward system in animal models, potentially dampening the reinforcing properties of addictive substances

1 Higher doses explicitly used for weight management (Wegovy 2.4 mg) in the STEP trials showed greater weight loss of around 15% of body weight

It is well established that the -cell trophic and metabolic modulation effect of prolactin is not limited to the period of pregnancy (41, 42)

This can slow down gastric emptying, leading to a feeling of fullness and, sometimes, nausea

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