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Description
Beginning at 2 mg weekly rather than 4 mg sharply cuts early GI events [4]

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Outcomes data will help trigger and inform new health economic evaluations of these drugs

doi:10.1016/S2213-8587(18)30023-8 23

No response to voice or physical stimuli -4 Deep sedation

But this introduces variables around absorption rate and systemic exposure that can complicate preclinical model design
