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Published data (SURMOUNT-4 trial) show most patients regain a meaningful portion of lost weight after discontinuation

Positive expression of GLP-1R is detected in the GCL of olfactory bulb (Thiebaud et al., 2016)

However, only a small number of patients were included in the study, and median levels were not elevated even before the commencement of GLP-1 RAs treatment (102)

The STEP 1 extension study showed that participants who stopped semaglutide regained approximately two-thirds of their lost weight within a year

Many users report feeling improvements within a few weeks, while more significant and sustained benefits are typically observed after three months of regular use

Notably, WAT from obese individuals, both in human and mice studies, contained a higher number of mast cells, macrophages, and lymphocytes compared to the lean groups