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However, studies found people with an average BMI of 38 using tirzepatide in conjunction with lifestyle changes and a reduced calorie diet lost about 21% of their body weight or 48.5 pounds versus about 7 pounds in those who did not use the drug

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This is part of how it reduces appetite and promotes weight loss

Clinical trials have shown that patients using tirzepatide achieved greater reductions in blood sugar compared to those using other medications