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2022;8:e164
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Research within the paper also reported that core patents on semaglutide are set to expire in 10 countries in 2026, including China, India and Canada from March 21 - opening the market up to generic competition - and identified a further 150 countries were patents had not been filed

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and overall duration

The primary mechanisms include: Enhanced insulin secretion in response to elevated blood glucose levels, helping to lower blood sugar in people with type 2 diabetes Suppression of glucagon release from the pancreas, reducing glucose production by the liver Delayed gastric emptying , which slows the movement of food from the stomach into the small intestine Increased satiety through actions on appetite centres in the brain, leading to reduced food intake The slowing of gastric emptying is particularly significant when considering electrolyte balance
