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Upper/Lower Gastrointestinal Symptoms Adverse event reporting databases, RCTs, and real-world data consistently show that GLP-1 RAs are commonly associated with GI symptoms such as nausea, vomiting, diarrhea, constipation, abdominal pain, and dyspeptic complaints

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Views expressed in this editorial are those of the authors and not necessarily the views of the ACS

You might also need to work closely with your healthcare provider to monitor blood sugar levels, weight changes, and overall health during this period

The TRIUMPH-4 Phase 3 trial in obesity with knee osteoarthritis later reported 28.7% mean weight loss at 68 weeks with retatrutide 12 mg/week, and identified a dose-related dysesthesia (nerve-tingling) signal in 8.8% of 9 mg and 20.9% of 12 mg patients (Bays et al., 2025)

Additionally, aldehyde reagents used in formulation increase the risk of impurity formation