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In a Phase 2 randomised controlled trial published in The New England Journal of Medicine (Jastreboff et al., 2023), participants without type 2 diabetes receiving the highest doses of retatrutide achieved mean body weight reductions of approximately 24% over 48 weeks

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The analysis found that people taking GLP-1 or GLP-1/GIP drugs were diagnosed with SIBO about twice as often as those taking other diabetes medications

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Structured physical activity enhances vascular and metabolic health, increases neurotrophic signaling, strengthens synaptic plasticity, and bolsters mitochondrial resilience, with benefits documented across aging, AD, and PD populations (228230)

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