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consumers (Amin et al., 2023)

Weight-related conditions (tied to other diagnoses): Semaglutide may qualify when excess weight contributes to conditions such as high blood pressure, sleep apnea, or cardiovascular risk

GLP-1 medications contain synthetic substances called glucagon-like peptide-1 receptor agonists (GLP-1 RAs), which mimic the natural GLP-1 hormone

Mechanisms of weight regain

GLP-1 is secreted physiologically by enteroendocrine L-cells of the small and large intestine, and GIP is secreted by duodenojejunal K-cells in response to food intake [23]

GLP-1 medications are expensive, often exceeding $1,000 per month, and insurance coverage for off-label addiction use is uncertain