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Maintenance doses range from 5 mg to 15 mg for weight management and up to 15 mg for type 2 diabetes, depending on individual response and tolerability

14 At the same time, GLP-1RAs can also inhibit glucagon secretion from pancreatic -cells

In Phase 2 data published in The New England Journal of Medicine , retatrutide achieved up to about 24.2% mean body weight reduction at 48 weeks at the highest dose

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This was associated with elevations in insulin secretion, improved glucose tolerance, and decreased hepatic TG accumulation in the livers of HFD-fed mice

J Clin Endocrinol Metab 96: 22272235, 2011