glp-1 receptor agonists mechanism of action Current Insights, Advantages and Challenges Small Molecule Glucagon-like Peptide 1 Agonists: A Scoping Review Frontiers | GLP−1 receptor agonists

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[DOI] [PMC free article] [PubMed] [Google Scholar] 52.Meloni A., et al

Aten Primaria (2017) 49:2949

Over time, some of these agents (in particular, GLP-1 agonists and SGLT2 inhibitors), which were initially developed for their glucose-lowering actions, have demonstrated significant beneficial pleiotropic effects, thus expanding their potential therapeutic applications

When GLP-1 is secreted from L-cells through the TGR5 agonist, it stimulates GLP-1R in enterochromaffin cells and induces serotonin or 5-hydroxytryptamine (5-HT) secretion from these cells

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