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Ellegaard AM, Krhus ML, Winther-Jensen M, Lund AB, Knop FK

Retatrutide, with triple-target effects (it works at the two receptors mentioned above and the glucagon receptor), caused people to lose about a quarter of their body weight after a year in a Phase II study (Jastreboff AM et al, N Engl J Med 2023;389(6):514526), although a follow-up study found the weight loss more in line with tirzepatide

Summary: There is no clinical evidence proving morning or night is superior for retatrutide

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Novo Nordisks pill version of Wegovys active ingredient, semaglutide, is priced at $968.52