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A single injection of 42 g/kg exenatide reduced circulating levels of IFN-, TNF-, and IL-2 in mice challenged with agonistic anti-CD3 antibodies, which broadly activate T cells and provokes systemic and gut inflammation (34)

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In 1959, Roger Unger generated and characterized the first glucagon-detecting antibody and thus paved the path to the development of the first radioimmunoassays (RIA) to detect glucagon in blood and tissue samples [20]