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JAMA 313 , 2263 (2015)

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However, available extension studies suggest that the benefits of dual agonism are maintained over time, with some patients experiencing continued improvement beyond the initial treatment period

Hormonal Crosstalk and Metabolic Integration in Reward Modulation The therapeutic effects of GLP-1RAs extend beyond isolated receptor pathways, engaging broader neuroendocrine networks that regulate energy balance, mood, and motivation

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