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Overall, hypogonadism prevalence in males with T2DM ranges from 26% to 48%, considering total T (TT) serum levels [21-26] , and from 19% to 57%, evaluating free T (FT) [21,22,24,25,27,28]

Patients should report persistent stool changes to their GP, particularly if accompanied by abdominal pain, as GLP-1 therapy carries rare risks of pancreatitis and gallbladder disease

Metabolic syndrome is often associated with disruption of circadian rhythm of systemic hemodynamics and cardiovascular disease

CaMK: calmodulin-dependent protein kinase

Maintaining a healthy muscle mass is not only crucial for physical strength and performance, but it also plays a vital role in overall metabolic health

AT A GLANCE Originally FDA-approved for type 2 diabetes, glucagon-like peptide-1 receptor agonists (GLP-1 RAs) also lead to sustained weight loss and have revolutionized diabetes and obesity management