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Ideally, novel risk equations should be developed incorporating data from CVOTs, and this should be the focus of future research in the area

So it's not that it needs to be one to three
The degree of this effect varies between individuals based on semaglutide dose, duration of therapy, and your genetic predisposition to peptide sensitivity
instead, go to the emergency department or call 911 if symptoms are acute

Nonetheless, the effect of GLP-1 RAs on HR should not be overlooked, because studies have shown that an elevated HR was potentially associated with a higher cardiovascular risk [353637]

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