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GLP-1RAs aid in weight loss by regulating the gut-brain axis and interacting with leptin, while weight loss can alleviate the harmful effects of obesity on the body, particularly in knee OA, by reducing joint loading and inflammation

Step four: ongoing support and check-ins Peak Wellness includes monthly check-ins, dose adjustments, and provider portal access as part of your subscription

Temperature monitoring considerations: During summer travel or in warm vehicles, avoid leaving medication in cars, where temperatures can rapidly exceed safe limits

Food intake: Track total calories and protein grams daily

Hypersensitivity reactions: stop using the GLP-1 agonist and get medical help right away if you have any symptoms of a serious allergic reaction including swelling of your face, lips, tongue or throat, severe rash or itching, very rapid heartbeat, problems breathing or swallowing, fainting or feeling dizzy

Why Combining These Treatments Works Using GLP-1 agonists alone can lead to great weight loss, but some patients experience challenges such as muscle loss, disproportionate fat loss, or loose skin