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In a phase I clinical trial, patients who were overweight or obese were able to reduce their body weight by 4.8% (3 mg dosage), 6.4% (4.5 mg), and 6.0% (6 mg) after receiving a once-weekly dose of mazdutide [51]

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The study enrolled adults with overweight or obesity and cardiovascular disease

And in addition to causing your pancreas to release insulin, Semaglutide also blocks a hormone that causes your liver to release sugar (glucagon)

Serotonin is produced by specific neurons localized in raphe nuclei in the brainstem (Llewellyn-Smith et al., 2013)